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Pro and Anti-Inflammatory Factors in Patients with Rhegmatogenous Retinal Detachment with Silicone Oil Tamponade

  • Ahdini Zulfiana Abidin ,
  • Budu ,
  • Andi Muhammad Ichsan ,
  • Habibah Setyawati Muhiddin ,
  • Hasnah Eka ,


Introduction: Rhegmatogenous retinal detachment (RRD) is the most common type of detachment, followed by exudative and tractional detachment. Pathogenic changes in the retina (including angiogenesis and fibrosis) trigger local inflammation and infiltration of leukocytes of the choroid, retina, and vitreous, which is also found in proliferative vitreoretinal detachment. Silicone oil, as a temporary tamponade used in the RRD, can cause immunological reactions in the tissue and may become one of the causes of increasing levels of inflammatory mediators in the eye. This literature review aims to determine the pro- and anti-inflammatory factors found in patients with RRD and patients with silicone oil tamponade.

Methods: This literature review utilised reliable databases such as Pubmed, Proquest, and Google Scholar from 2013 until 2023. The main keywords “rhegmatogenous retinal detachment” and “silicone oil” were used, including some additional keywords, to collect eight journals that had relevant topics.

Result: Variations of inflammatory markers were found in many studies, and some correlated with proliferative vitreoretinopathy (PVR) development, the extent of detachment and the recurrence of redetachment in some cases.

Conclusion: A rise in various cytokines can mediate the wound-healing process in RRD, specifically involving retinal pigment epithelium and glial cells, fibroblasts, and inflammatory cells in eyes with retinal tears. This trend of high activity of RPE cells also appeared in eyes with vitreous cavities replaced by silicone oil (SO). The selection of tamponade preference should be based on the extent of the injury, patients’ needs, and surgeons’ expertise.


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How to Cite

Zulfiana Abidin, A., Budu, Ichsan, A. M. ., Muhiddin, H. S. ., & Eka, H. . (2023). Pro and Anti-Inflammatory Factors in Patients with Rhegmatogenous Retinal Detachment with Silicone Oil Tamponade. Bali Medical Journal, 13(1), 350–355.




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