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The role of urine Angiotensin-II (ANG-II) in predicting the occurrence of Acute Kidney Injury (AKI) induced by sepsis in children

  • Arwini Avissa Abdullah ,
  • Idham Jaya Ganda ,
  • St. Aizah Lawang ,


Link of Video Abstract:


Background: The incidence of AKI has increased by 2.8% per year. Sepsis is one of the main causes of AKI. Sepsis is a major cause of intensive care unit (ICU) mortality and morbidity in developing countries. ANG-II is an active peptide of the renin-angiotensin system (RAAS) that activates pro-inflammatory and pro-fibrotic pathways associated with the development of AKI. This study aims to identify the role of urinary angiotensin-II (ANG-II) in predicting the occurrence of acute renal impairment due to sepsis in children.

Methods: This study was an observational study with a prospective cohort approach. The population of this study were sepsis patients who initially did not experience AKI aged 1 month to 18 years who were hospitalized in the PICU with a total sample of 40 samples. Data were analyzed using SPSS version 25.0 for Windows.

Results: Based on the results of statistical tests using univariate tests, it was found that there was an association between ANG-II values and AKI in pediatric patients with sepsis, with higher values in children with AKI. Urinary Angiotensin-II value of 207.63 ng/ml is a predictor value of AKI in pediatric patients with sepsis with a sensitivity value of 76.7% and sensitivity of 70%.

Conclusion: This study concludes that urinary Angiotensin-II value can be used to predict the incidence of AKI in pediatric patients with sepsis.


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How to Cite

Abdullah, A. A., Ganda, I. J., & Lawang, S. A. (2024). The role of urine Angiotensin-II (ANG-II) in predicting the occurrence of Acute Kidney Injury (AKI) induced by sepsis in children. Bali Medical Journal, 13(1), 715–721.




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Arwini Avissa Abdullah
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Idham Jaya Ganda
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St. Aizah Lawang
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